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What is the difference between synthetic and natural vitamin c?

Wondering about the bioavailability regarding vitamin c from natural or sythetic sources. I am specifically looking for studies or scientific proof of the negative effects of sythetic vitamins and specifically vitamin c.

Public Comments

1. Anything synthetic is man made, and does not come from natural extracts.
2. Vitamins are made up of several different components enzymes, co-enzymes, and co-factors– that must work together to produce their intended biologic effects.Vitamins that are found naturally in whole foods come with all of their necessary components.The majority of vitamins that are sold in pharmacies, grocery stores, and vitamin shops are synthetic vitamins, which are only isolated portions of the vitamins that occur naturally in food.
3. Most brands of supplements available today are made from synthetics (you could synthesize from petroleum-based byproducts). These "vitamins" are chemical compounds that have been manufactured in laboratory to copy the molecular structure of natural vitamins. Your body is designed to absorb nutrients from food. For this reason most health experts agree that it is best to obtain your daily vitamin supplement from whole food, (real food) than from synthetic vitamin sources.